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  1.Title:

Role of Adenosine A2A Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington’s Disease    

  Authors:

Tebano, Maria Teresa ; Martire, Alberto ; Chiodi, Valentina ; Ferrante, Antonella ; Popoli, Patrizia  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1768-1782 
  Date of publication:

1/9/2010 
  Article Type:

Review Article 
  Handling Editor:

Sergi Ferre 
  Domains: Neuroscience , Pathology , Pharmacology , Drug Discovery , Neurology , Learning & Memory , Cell Signaling , Gene, Molecular & Cell Therapy , Proteins & Proteomics , Intercellular Communication  
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  Synopsis: This article seeks to review the current knowledge about the cross-talk between adenosine A2A receptors (A2ARs) and brain-derived neurotrophic factor (BDNF). A2ARs exert a great influence on the activation of BDNF receptors and on the effect that the neurotrophin has on synaptic transmission. These and other A2ARs functions will be reviewed and discussed in the light of possible A2ARs-based therapeutic approaches in Huntington’s disease, in which a pathogenetic role of BDNF has been shown. 
  2.Title:

Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer’s Disease

  Authors:

Suo, William Z.; Li, Longxuan  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1667-1678 
  Date of publication:

17/8/2010 
  Article Type:

Mini-Review Article 
  Handling Editor:

Rudy Tanzi 
  Domains: Neuroscience , Cell Biology , Pathology , Aging , Cognition , Neurology , Psychiatry , Biophysics , Cell Signaling , Immunology & Inflammation , Proteins & Proteomics  
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  Synopsis: The signal transduction deficits in Alzheimer’s disease (AD) converge to the receptor-G protein interface, where G protein-coupled receptor kinases (GRKs) act. Beta-Amyloid can decrease membrane and increase cytosolic GRK2/5. GRK2 accumulates near damaged mitochondria and neurofibrillary tangles, and correlates with cognitive decline. The GRK5 deficiency impairs presynaptic M2 desensitization, reduces acetylcholine release, and leads to cholinergic degeneration and cognitive impairment. It also promotes Beta-amyloid accumulation and exaggerates brain inflammation; therefore, it appears to be closely involved in the AD pathogenesis. 
  3.Title:

Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons

  Authors:

Ma, Xin-Ming  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1655-1666 
  Date of publication:

17/8/2010 
  Article Type:

Mini-Review Article 
  Handling Editor:

Sergi Ferre 
  Domains: Neuroscience , Cell Biology , Drug Dependence , Behavior , Cognition , Neurology , Learning & Memory , Psychiatry , Cell Signaling , Development & Embryology , Proteins & Proteomics , Biochemistry & Molecular Biology  
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  Synopsis: Understanding the underlying molecular mechanisms of synapse formation and development that are associated with learning and memory is of great interest. This article summarizes our current understanding of Kalirin-7 (Kal7) functions, briefly describing how Kal7 regulates spine/synapse formation in hippocampal neurons, and addressing the roles of Kal7 in estrogen- and chronic cocaine exposure–mediated spine plasticity. Kal7 is a key component of mature excitatory synapses and is essential for specific aspects of excitatory synapse formation and function in hippocampal neurons. 
  4.Title:

Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands    

  Authors:

Hunter, Cheryl ; Kadakia, Tejas B.; Cooper, Dianne ; Perretti, Mauro ; Schwartz, Richard C.; Brown, Simon B. 
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1580-1596 
  Date of publication:

17/8/2010 
  Article Type:

Research Article 
  Handling Editor:

Marco A. Cassatella 
  Domains: Neuroscience , Cell Biology , Toxicology , Pharmacology , Cell Signaling , Gene, Molecular & Cell Therapy , Genes & Genomics , Immunology & Inflammation , Proteins & Proteomics , Biochemistry & Molecular Biology  
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  Synopsis: Perturbations in ion gradients that exist across the plasma membrane of living cells have profound effects on cell viability, metabolism, and functional responses. Potassium permeability will influence the proinflammatory responses of macrophages, although the mechanisms remain poorly defined. This report details how inhibitors of a specific potassium ion channel can regulate the activity of macrophage cdk2, a key kinase involved in augmenting the expression of interleukin-6 that is instrumental in regulating an inflammatory response. 
  5.Title:

FHIT: Doubts are Clear Now

  Authors:

Wali, Anjilna  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1142-1151 
  Date of publication:

16/6/2010 
  Article Type:

Mini-Review Article 
  Handling Editor:

Marc Lippman 
  Domains: Oncology , Cell Fate & Determination , Cell Biology , Experimental Medicine , Cell Signaling , Genes & Genomics , Proteins & Proteomics , Intercellular Communication , Biochemistry & Molecular Biology  
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  Synopsis: Decreased expression of Fhit (fragile histidine triad) has been detected in various tumors, including esophageal, lung, colorectal, cervical, prostate, and hepatocellular carcinomas, as compared to the corresponding normal counterparts. This article highlights the various mechanisms by which the Fhit protein helps in the reduction of tumor formation. 
  6.Title:

Molecular Circuits of Resolution in the Eye

  Authors:

Liclican, Elvira L; Gronert, Karsten  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

1029-1047 
  Date of publication:

1/6/2010 
  Article Type:

Review Article 
  Handling Editor:

Joan Clària 
  Domains: Neuroscience , Cell Biology , Cardiovascular Biology , Cell Signaling , Immunology & Inflammation , Proteins & Proteomics , Biochemistry & Molecular Biology  
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  Synopsis: Execution of a perfectly balanced acute inflammatory/reparative response is nowhere as critical and conserved as in the delicate visual axis, as uncontrolled inflammation impairs vision and leads to blindness. In this regard, lipid autacoid circuits have emerged as key components of endogenous pathways that preserve ocular function and limit the sequelae of ocular injury. This review summarizes the current state of the field regarding the protective endogenous lipid circuits in the ocular/inflammatory response. 
  7.Title:

Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival

  Authors:

Lossi, Laura ; Gambino, Graziana ; Salio, Chiara ; Merighi, Adalberto  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

924-929 
  Date of publication:

18/5/2010 
  Article Type:

Directions in Science 
  Handling Editor:

Sergi Ferre 
  Domains: Neuroscience , Cell Fate & Determination , Cell Biology , Neurology , Development & Embryology , Proteins & Proteomics  
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  Synopsis: The mechanisms of neuroprotection are still largely incompletely known. We report here some findings on the role of autophagy, a cellular process by which unwanted/damaged organelles or proteins are eliminated, in the regulation of the cellular levels of BCL-2, one of the most widely investigated proteins that protects cells from death. 
  8.Title:

Resolution of Adipose Tissue Inflammation

  Authors:

González-Périz, Ana ; Clària, Joan  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

832-856 
  Date of publication:

4/5/2010 
  Article Type:

Review Article 
  Handling Editor:

Charles N. Serhan 
  Domains: Nutrition , Cell Signaling , Gene, Molecular & Cell Therapy , Immunology & Inflammation , Metabolism & Metabolic Disease , Intercellular Communication , Biochemistry & Molecular Biology  
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  Synopsis: Obesity involves a state of chronic “low-grade” inflammation in adipose tissue, which predisposes to obesity-related comorbidities, such as insulin resistance and nonalcoholic fatty liver disease. Although omega-6 PUFA–derived proinflammatory eicosanoids initially trigger the inflammatory response, in time, there is a switch to the formation of anti-inflammatory and proresolving omega-3 PUFA–derived lipid autacoids, such as resolvins and protectins, which participate in the resolution of adipose tissue inflammation and in preventing the development of obesity-related complications. 
  9.Title:

Recent Insights into the Implication of Nitric Oxide in Osteoblast Differentiation and Proliferation during Bone Development

  Authors:

Saura, Marta ; Tarin, Carlos ; Zaragoza, Carlos  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

624-632 
  Date of publication:

13/4/2010 
  Article Type:

Mini-Review Article 
  Handling Editor:

Martin Goette 
  Domains: Bone Biology , Cell Fate & Determination , Cell Biology , Pharmacology , Cell Signaling , Development & Embryology , Biochemistry & Molecular Biology  
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  Synopsis: The recent advances towards investigation in osteogenesis have provided significant information about the transcriptional regulation of several genes, including matrix metalloproteinases, by the expression of crucial transcription factors like NFAT, ATF4, osterix, TAZ, and Runx2 responsive elements. Recently, in vitro data showed that Cbfa-1 and the MAPK pathways were crucial for osteoblastic cell differentiation, and nitric oxide was found to play a significant role 
  10.Title:

Multiple Functions of Phosphoinositide-3 Kinase Enhancer (PIKE)

  Authors:

Chan, Chi Bun ; Ye, Keqiang  
  Journal:

TheScientificWorldJOURNAL 
  Page Range:

613-623 
  Date of publication:

13/4/2010 
  Article Type:

Mini-Review Article 
  Handling Editor:

Martin Goette 
  Domains: Neuroscience , Oncology , Cell Fate & Determination , Cell Biology , Toxicology , Cell Signaling , Genes & Genomics , Proteins & Proteomics , Biochemistry & Molecular Biology  
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  Synopsis: This article seeks to review the current methods of diagnosis, treatment, and long-term care fore children with megaureter. There is a specific emphasis on the early detection of megaureter using prenatal ultrasound to identify hydronephrosis, and how this has highlighted the limitations in our diagnoses of clinically significant obstruction in infants. 

Articles 1 - 10 of 125

  

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