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Title: |
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New Perspectives on Aspirin and the Endogenous Control of Acute Inflammatory Resolution |
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Authors: |
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Morris, Thea ; Stables, Melanie ; Gilroy, Derek W. |
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Journal: |
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TheScientificWorldJOURNAL |
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Year: |
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2006 |
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Volume: |
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6 |
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Page Range: |
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1048-1065 |
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Article Type: |
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Review Article |
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Handling Editor: |
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Charles N. Serhan |
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Domains: |
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Pharmacology
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Drug Discovery
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Cardiovascular Biology
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Cell Signaling
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Immunology & Inflammation
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Biochemistry & Molecular Biology
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DOI: |
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10.1100/tsw.2006.192 |
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Synopsis: |
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Aspirin’s widespread popularity stems from its impressive array of properties beneficial in a multitude of disease states. Such properties have been exploited and used mainly in the treatment and prevention of inflammatory conditions and cardiovascular diseases. Despite aspirin’s well established benefits, there still remains a certain degree of confusion as to how aspirin actually works. This review highlights the work, past and recent, undertaken to elucidate the mystery of aspirin and its hidden secrets. |
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Keywords: |
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Inflammation, Resolution, Nitric oxide, NSAIDs |
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Abstract |
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Aspirin is unique among the nonsteroidal anti-inflammatory drugs in that it has both anti-inflammatory as well as cardio-protective properties. The cardio-protective properties arise form its judicious inhibition of platelet-derived thromboxane A2 over prostacyclin, while its anti-inflammatory effects of aspirin stem from its well-established inhibition of prostaglandin (PG) synthesis within inflamed tissues. Thus aspirin and the other NSAIDs have popularised the notion of inhibiting PG biosynthesis as a common anti-inflammatory strategy based on the erroneous premise that all eicosanoids are generally detrimental to inflammation. However, our fascination with aspirin has shown a more affable side to lipid mediators based on our increasing interest in the endogenous control of acute inflammation and in factors that mediate its resolution. Epi-lipoxins (epi-LXs), for instance, are produced from aspirin’s acetylation of inducible cyclooxygenase 2 (COX-2) and together with Resolvins represent an increasingly important family of immuno-regulatory and potentially cardio-protective lipid mediators. Aspirin is beginning to teach us what nature knew all along – that not all lipid mediators are bad. It seems that while some eicosanoids are pathogenic in a variety of diseases, others are unarguable protective. In this review we will re-count aspirin’s colorful history, discuss its traditional mode of action and the controversies associated therewith, as well as highlight some of the new pathways in inflammation and the cardiovascular systems that aspirin has recently revealed. |
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Chen Gang
Posted 4th November 2007 |
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Can I get the full text PDF? I am very interested in this article. Thank you very much. |
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aiping bai
Posted 19th March 2007 |
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I want to get the original paper, thanks! |
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Fan Ying
Posted 11th December 2006 |
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Can I get the full text?I am very interested in this article.Thanks a lot. |
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