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Title: |
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Repeat Intrathecal Triamcinolone Acetonide Application Reduces Acute Occurring Painful Dysesthesia in Patients with Relapsing Remitting Multiple Sclerosis |
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Authors: |
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Hellwig, Kerstin ; Lukas, Carsten ; Brune, Niels ; Hoffmann, Volker ; Schimrigk, Sebastian ; Przuntek, Horst ; Müller, Thomas |
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Journal: |
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TheScientificWorldJOURNAL |
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Year: |
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2006 |
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Volume: |
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6 |
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Page Range: |
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460-465 |
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Article Type: |
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Case Study |
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Handling Editor: |
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George Siegel |
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Domains: |
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Pharmacology
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Neurology
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Immunology & Inflammation
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DOI: |
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10.1100/tsw.2006.86 |
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Synopsis: |
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Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. MS patients sometimes suffer from painful sensations due to inflammatory lesions of the spinal cord. We report on a distinct reduction of pain after repeat intraspinal application of a retarded steroid preparation. This kind of treatment provided substantial therapeutic benefit for these MS patients. |
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Keywords: |
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relapsing remitting multiple sclerosis, triamcinolone acetonide, intrathecal, dysesthesia, therapy |
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Abstract |
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We describe four patients with relapsing remitting multiple sclerosis (RRMS) who experienced a relapse with acute onset of painful sensations. Pain sensations disappeared in two of them and markedly reduced in the other ones after repeat application of intrathecal triamcinolone acetonide (TCA) following a prior unsuccessful treatment with intravenous steroids. TCA administration was well tolerated and no serious side effects occurred. Repeated intrathecal TCA injection may provide a substantial benefit in RRMS patients with acute onset of pain due to an inflammatory lesion within the spinal cord. |
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