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Title: |
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Genetic Damage Induced by Accidental Environmental Pollutants |
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Authors: |
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Pérez-Cadahía, Beatriz ; Laffon, Blanca ; Pásaro, Eduardo ; Méndez, Josefina |
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Journal: |
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TheScientificWorldJOURNAL |
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Year: |
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2006 |
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Volume: |
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6 |
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Page Range: |
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1221-1237 |
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Article Type: |
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Review Article |
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Handling Editor: |
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Demetrios Matthopoulos |
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Domains: |
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Environmental Chemistry
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Toxicology
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Microscopy
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Aquatic Toxicology
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Genes & Genomics
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DOI: |
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10.1100/tsw.2006.206 |
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Synopsis: |
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Prestige oil tanker wrecked in November 2002 in front of the coast of Galicia (Northwest of Spain), spilling near 63,000 tons of crude oil. The objective of this work was to determine the possible genotoxic damage induced on the human population involved in the different cleaning tasks. Increased DNA damage, but almost no cytogenetic damage, was observed in the exposed population as compared to controls. Results were not influenced by the use of protective devices. |
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Keywords: |
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accidental pollutants, genotoxicity, micronucleus (MN) test, sister chromatid exchanges (SCE), comet assay |
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Abstract |
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Petroleum is one of the main energy sources worldwide. Its transport is performed by big tankers following some established marine routes. In the last 50 years a total amount of 37 oil tankers have given rise to great spills in different parts of the world, Prestige being the last one. After the accident, a big human mobilisation took place in order to clean beaches, rocks and fauna, trying to reduce the environmental consequences of this serious catastrophe. These people were exposed to the complex mixture of compounds contained in the oil. This study aimed at determine the level of environmental exposure to volatile organic compounds (VOC), and the possible damage induced on the population involved in the different cleaning tasks by applying the genotoxicity tests sister chromatid exchanges (SCE), micronucleus (MN) test, and comet assay. Four groups of individuals were included: volunteers (V), hired manual workers (MW), hired high-pressure cleaner workers (HPW) and controls. The higher VOC levels were associated with V environment, followed by MW and lastly by HPW, probably due to the use of high-pressure cleaners. Oil exposure during the cleaning tasks has caused an increase in the genotoxic damage in individuals, the comet assay being the most sensitive biomarker to detect it. Sex, age and tobacco consumption have shown to influence the level of genetic damage, while the effect of using protective devices was less noticeable than expected, perhaps because the kind used was not the most adequate. |
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najeh
Posted 26th March 2007 |
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very good |
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