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Title: |
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The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update |
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Authors: |
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Maarabouni, Mirna M; Williams, Gwyn T |
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Journal: |
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TheScientificWorldJOURNAL |
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Year: |
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2006 |
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Volume: |
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6 |
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Page Range: |
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1705-1712 |
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Article Type: |
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Mini-Review Article |
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Handling Editor: |
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Martin Goette |
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Domains: |
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Oncology
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Cell Fate & Determination
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Cell Biology
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Cell Cycle
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Proteins & Proteomics
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Biochemistry & Molecular Biology
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DOI: |
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10.1100/tsw.2006.268 |
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Synopsis: |
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LUCA-15 gene is located at a hotspot for deletions in a number of cancers. It is considered as a putative tumour suppressor gene. A number of lines of evidence supports this hypothesis and indicates LUCA-15 involvement in apoptosis. Functional, structural and mechanistic studies to clarify the function of LUCA-15 could lead to the development of new diagnostic and therapeutic approaches for human cancer. |
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Keywords: |
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T-lymphocytes, LUCA-15, RBM5; H37, RNA-binding proteins, cell death, cell proliferation |
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Abstract |
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The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene. |
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