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TheScientificWorldJOURNAL (ISSN 1537-744X) |
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Title: |
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Cardiovascular Activities of of the bradykinin system |
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Authors: |
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Sharma, Jagdish N. |
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Journal: |
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TheScientificWorldJOURNAL |
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Year: |
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2008 |
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Volume: |
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8 |
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Page Range: |
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384-393 |
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Article Type: |
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Research Article |
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Handling Editor: |
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Peter Little |
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Domains: |
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Nephrology
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Neuroscience
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Endocrinology
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Pharmacology
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Drug Discovery
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Cardiovascular Biology
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Motility
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Cell Signaling
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Intercellular Communication
,
Biochemistry & Molecular Biology
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DOI: |
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10.1100/tsw.2008.53 |
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Keywords: |
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kallikrein-kinin system, cardioprotection, hypertension, cardiac diseases, angiotensin-converting enzyme inhibitors |
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Abstract |
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All the components of the kallikrein-kinin system are located in the cardiac muscle and
its deficiency may lead to cardiac dysfunction. In recent years, numerous observations
obtained from clinical and experimental models of diabetes, hypertension, cardiac
failure, ischemia, myocardial infarction, and left ventricular hypertrophy have suggested
that the reduced activity of the local kallikrein-kinin system may be instrumental for the
induction of cardiovascular-related diseases. The cardioprotective property of the
angiotensin-converting enzyme inhibitors is primarily mediated via a kinin-releasing
pathway, which may cause regression of the left ventricular hypertrophy in hypertensive
situations. The ability of kallikrein gene delivery to produce a wide spectrum of beneficial
effects makes it a promising candidate in treating hypertension and cardiovascular and
renal diseases. In addition, stable kinin agonists may also be available in the future as
therapeutic agents for cardiovascular and renal disorders. However, there are also
possibilities of adverse effects that may be caused by these compounds. |
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